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Explore dynamic office space in South San Francisco, a city in California known for its innovative business culture and growth potential. With locations in Oyster Point and Downtown South San Francisco, our rentable office spaces cater to biotech and pharmaceutical industries, providing flexible workspace options near major transport hubs like SFO and the South San Francisco BART Station.

Settle into a thoughtfully designed, private workspace that fosters focus and creativity. Every office is built to support your best work.
Customize your office space to match your team's style and workflow. Flexible arrangements adapt easily as your business evolves.
Benefit from seamless support services, ensuring your team can focus on the bigger picture. Our friendly professionals handle the details, from reception to tech support.
Join an energized community of professionals, with regular opportunities to network, collaborate, and grow.
Discover office spaces crafted for creativity and connection in South San Francisco












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Shape a space that fits your flow—smart, stylish, and built to elevate your workday.


Desks
Choose the right surface for how you work — from sit-stand desks to spacious executive setups, each option supports productivity and comfort.
Chairs
Stay supported all day with ergonomic seating. Adjustable features and lumbar support help keep focus high and strain low.
Meeting spaces
Add a spot for quick check-ins or in-depth discussions. Go formal with a boardroom table or keep it relaxed with a café-style setup.
Furniture options
Bring warmth and personality to your space with soft seating, greenery, and purposeful décor that supports both focus and downtime.
Storage
Keep your workspace organised with under-desk drawers, shelving, or secure cabinets — everything within reach, nothing in the way.
Find your ideal workspace, wherever work takes you.
South San Francisco* is a vibrant city in California, offering numerous growth opportunities for businesses. With a population of approximately 67,000 residents, it is part of the larger San Francisco Bay Area market. Rent office space here and take advantage of its strong growth potential, thanks to its proximity to San Francisco and Silicon Valley. This city is known for its collaborative and innovative business environment, making it an ideal location for forward thinkers, innovators, and game changers.
South San Francisco boasts several key commercial areas perfect for office space rental. Oyster Point is a prominent district focused on biotechnology and life sciences, offering furnished office space that caters to these industries. Lease office space in Downtown South San Francisco, a mixed-use area with retail, dining, and office spaces, creating a dynamic workday experience. El Camino Real is another major thoroughfare with various commercial establishments, ideal for flexible office space.
Office space for rent* in South San Francisco means connecting with notable employers like Genentech, Amgen, Thermo Fisher Scientific, and UPS. These companies foster a culture of research and development, perfect for businesses in biotechnology, pharmaceuticals, manufacturing, and logistics. Rentable office space here allows you to be part of this thriving community. The city is also well-connected with transport hubs like the South San Francisco BART Station, providing rapid transit connections to San Francisco and other Bay Area locations. Lease office space near the San Francisco International Airport (SFO) for easy access to domestic and international flights.
South San Francisco offers various retail and leisure options, enhancing your work-life balance. The Shops at Tanforan is a major shopping center with retail stores, dining options, and entertainment facilities. Explore local restaurants offering diverse culinary experiences during breaks or after office hours.
Office space to rent* in South San Francisco gives you access to the South San Francisco Medical Center, providing comprehensive healthcare services to residents and workers. The city's business regulations aligned with California state laws, including a corporate tax rate of 8.84% for general corporations in California, ensure a smooth operation for your business.
Spaces provides serviced office space tailored to your needs. Whether you're looking for executive suites for rent, private offices, or temporary office space, we offer move-in ready offices to help you think, create, and collaborate. Our dynamic workspaces with a unique and entrepreneurial spirit are perfect for shared office space or hybrid office space, making every corner an inspiring spot. Explore cheap office space with competitive office rental rates and office lease rates. With Spaces, you can find the office space cost per month that suits your budget while enjoying a sophisticated European design and a friendly community.
Rent an office for a day* or opt for month-to-month office solutions. We provide office space by the hour for those who need flexibility. Whether you need a small office space, large office space, or custom offices, Spaces in South San Francisco offers scalable solutions for businesses of all sizes.
Inspiring spaces* in South San Francisco where every corner sparks new ideas. Collaborate freely, design your perfect workday with Spaces. Explore the vibrant commercial areas, connect with major industries, and enjoy the buzz of this dynamic city. Office space for lease in South San Francisco is more than just a workplace; it's a community of positive, open-minded business thinkers. Join us and expand your horizon in a city known for its innovation and growth.
Are small offices available in South San Francisco?
Yes — Spaces offers compact, ready-to-move-in offices designed for individuals and small teams.
These can be booked monthly, daily, or even by the hour.
Contact us to check availability and arrange a visit.
Are Spaces offices in South San Francisco fully serviced?
Yes — every Spaces office is fully serviced. That means utilities, cleaning, and maintenance are included, so you can focus on your work from day one.
Each office comes with:
Some locations in South San Francisco also feature extras such as:
Can I visit to see office space in person in South San Francisco?
Absolutely. Visiting in person is the best way to explore our workspaces before making a decision.
Book a tour online here, or give us a call. You’re welcome to view multiple locations in South San Francisco to find the perfect fit for your team.
Do you provide enterprise-scale workspace in South San Francisco?
We do — Spaces provides dedicated solutions for larger organizations across in South San Francisco and in the United States. Options include:
Our enterprise team can work with you to build a workspace strategy that’s scalable and future-proof. Please get in touch to learn more.
Do you require a minimum rental period?
No — there’s no strict minimum with Spaces. You can rent an office for just a few weeks or stay for years. Our flexible contracts let you adapt as your business grows, scale your space up or down, or even change locations when needed.
Is it possible to book an office just for one day in South San Francisco?
Yes — you can book an office by the day with Spaces’ flexible options. Alongside day offices, we also offer offices by the hour, meeting rooms, and coworking desks.
With 29 Spaces locations in South San Francisco, day office prices start from $ 65 per person per day.
Bookings can be made online for individuals or teams of any size. Need multiple offices for the same day? Please contact us to explore your options.
Should I book office space in South San Francisco in advance?
We recommend booking ahead if you need a specific size, setup, or location.
If you have a long-term office, you’re free to arrive and start work whenever you like. For Hourly Offices or Day Offices in South San Francisco, advance booking via the Spaces app, phone, or online ensures your spot is ready for you.
What are the costs for renting an office in South San Francisco?
Our office spaces in South San Francisco start from $ 8 per person each day, based on a 24-month contract. The cost depends on a number of factors — including size, location, number of people, contract length, and the amenities you choose. Premium offices, such as those with executive layouts, single-person studios, or city views, are generally priced higher per person.
For flexibility, you can also choose an Office Space All Access Plan — available for individuals and teams — giving you private office access for 5, 10, or unlimited days each month.
What if I need office space in more than one location in South San Francisco?
With Spaces, you’re never tied to one place. Our Office Space All Access Plan and Cowork All Access Plan let you book offices or coworking desks across in South San Francisco and the country.
Choose 5, 10, or unlimited days per month — perfect for teams that move between neighborhoods, cities, or even countries.
Which types of office space are available in South San Francisco?
Spaces offers a variety of flexible office solutions in South San Francisco, suitable for both individuals and teams. Choose from:
Every office can be customized to suit your business — from adding extra desks and storage to bespoke layouts and artwork.
We also offer Specialized Spaces, tailored for industries such as healthcare, media, technology, and energy.
Discover the Spaces range of offices, coworking desks, meeting rooms and virtual offices near you.
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Still have questions? Contact us, we’re happy to help!
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611 Gateway Blvd Suite 120, South San Francisco, CA, 94080, USA

3 East Third Avenue Downtown San Mateo, Suite 200, San Mateo, CA, 94401, USA

1390 Market Street Civic Center, Suite 200, San Francisco, CA, 94102, USA

95 Third Street 2nd Floor, San Francisco, CA, 94103, USA

720 Market St 2nd Floor, San Francisco, CA, 94102, USA

71 Stevenson St Suite 400, San Francisco, CA, 94105, USA

101 Montgomery St. Suite 900, San Francisco, CA, 94111, USA

388 Market Street, San Francisco, CA, 94111, USA

580 California Street Financial District, 12th and 16th Floor, San Francisco, CA, 94104, USA

505 Montgomery Street 10th and 11th Floor, San Francisco, CA, 94111, USA

50 California Street Suite 1500, San Francisco, CA, 94111, USA

1160 Battery Street East Suite 100, San Francisco, CA, 94111, USA